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Increased incidence of polyps was not seen at crestor lower doses. How to take it Depending on daily your daily condition and ethnic background, your doctor will decide the daily most appropriate starting dose for you. Patients, pharmacists, and prescribers cannot seek reimbursement from health insurance or any third party for any part of the benefit received by the patient through this offer. After randomization, patients were treated for 6 weeks with a crestor single daily dose of either Crestor, atorvastatin, simvastatin, or pravastatin (Figure 1 and Table 7). These studies had a treatment duration of up to 12 weeks. Seek emergency medical attention or call the Poison Help line. Adolescent females should be counseled on appropriate contraceptive methods while on Crestor therapy see Use in Specific Populations (8.1). Make sure your doctor knows if you are Asian. Crestor Dosage daily and Administration, general Dosing Information. This drug daily may rarely cause muscle problems (which can rarely lead to very serious conditions called rhabdomyolysis and autoimmune myopathy). Although not all adverse reactions identified in the adult population have been observed in clinical trials of children and adolescent patients, the same warnings and precautions for adults should be considered for children and adolescents. Lipid-Modifying Effects of Rosuvastatin in Pediatric Patients 10 to 17 years of Age with Heterozygous Familial Hypercholesterolemia (Least-Squares Mean Percent Change from Baseline to Week 12) Dose (mg) N LDL-C HDL-C Total-C TG ApoB daily Placebo At the end crestor of the 12-week. There is no available information on the effects of the drug on the breastfed infant or the effects of the drug on milk production. Crestor 40mg are pink, oval, film-coated, biconvex tablets, crestor engraved "ZD4522" on one side and "40" on the other side. In 2010, daily the FDA approved Crestor for prevention of heart attacks, strokes and death among fairly healthy people with elevated C-reactive protein (CRP) levels. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Crestor can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Crestor therapy should also be temporarily withheld in any patient with an acute, serious condition suggestive of myopathy or predisposing to the development of renal failure secondary to rhabdomyolysis (e.g., sepsis, hypotension, dehydration, major surgery, trauma, severe metabolic, endocrine, and electrolyte disorders, or uncontrolled seizures). Gemfibrozil Gemfibrozil significantly increased rosuvastatin exposure. Retrieved m Wolfe,.M. Nonclinical Toxicology daily Carcinogenesis, Mutagenesis, Impairment of Fertility In a 104-week carcinogenicity study in rats at dose levels of 2, 20, 60, or 80 mg/kg/day by oral gavage, the incidence of uterine stromal polyps was significantly increased in females at 80 mg/kg/day. As a result, the FDA ordered a change in Crestors label. Study daily participants had a median baseline ldlc of 108 mg/dL and hsCRP.3 mg/L. Results are shown in the table below. Talk to your doctor before you start taking any new medicines. The jupiter study was stopped early by the Data Safety Monitoring Board due to meeting predefined stopping rules daily for efficacy in rosuvastatin-treated subjects. Your doctor or pharmacist can tell you what to do if you are taking any of these medicines. But in a February 2018 financial statement, AstraZeneca announced it had resolved all product liability lawsuits over Crestor. Wait at least 2 hours after taking Crestor to take an antacid that contains a combination of aluminum and magnesium hydroxide. Dose-Response in Patients with Hyperlipidemia (Adjusted Mean Change from Baseline at Week 6) Dose N TotalC ldlc Non-hdlc ApoB TG hdlc Placebo Crestor 5 mg Crestor 10 mg Crestor 20 mg Crestor 40 mg Active-Controlled Study: Crestor was compared with the hmgcoA reductase inhibitors atorvastatin. Doses 30 mg/kg/day (systemic exposures 60 times the human exposure at 40 mg/day based on AUC) did not reveal retinal findings during treatment for up to one year. Eligible cash-paying patients will receive up to 130 in savings on out-of-pocket costs per 30-day supply. General Information about the safe and effective use of Crestor Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Caution should be exercised when rosuvastatin is coadministered crestor with protease inhibitors see Dosage and Administration (2.4), Warnings and Precautions (5.1) and Clinical Pharmacology (12.3). Mean LDL-C at baseline was 233 mg/dL (range of 129 to 399). Data Human Data Limited published data on rosuvastatin have not shown an increased risk of major congenital malformations daily or miscarriage. Crestor can be taken 2 hours before or 2 hours after taking an antacid warfarin (e.g. Offer good for 12 uses; each 30-day supply counts as 1 use. If these rare effects occur, talk to your doctor. Program managed by pskw, LLC, on behalf of AstraZeneca. Crestor generally does not cause any problems with your ability to drive a car or operate machinery. Asian heritage been prescribed another class of lipid lowering agent called a fibrate been prescribed any medicine containing fusidic acid severe kidney impairment situations that may increase crestor blood levels.

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